Law of Parsimony – Simple Explanations to Explain Consequences

| November 6, 2017 | 0 Comments

Sooooooo, your rheumatologist does not know what causes rheumatoid arthritis (R. A.), your dermatologist does not know what causes eczema/psoriasis, your endocrinologist does not know what causes diabetes and your internist/family doctor does not know what causes high blood pressure. Is it just me or does that situation seem bizarre? Do you take your car to a mechanic who doesn’t understand why the oil light comes on?

I love reading and I love learning. My “dates” on Friday and Saturday nights were often at the Harrington Medical Library here in Amarillo. A favorite read was one of these “Review Articles” in which some smart people give an update on what we know about a particular disease.

Since just reading in and of itself is a pleasure, I’m not restricted to subject matter. I was just as interested to read review articles on rheumatology as I was dermatology, endocrinology and cardiology. What I started to notice was an S. O. S. pattern in the description of the pathogenesis of diseases across different specialties.

Note, in the third paragraph of the intro in the first picture at the bottom, two features of R. A. are given–“inflammation and hyperplasia”. If you’re a cardiologist, that should sound familiar because it’s exactly what happens in arterial walls to produce atherosclerosis. If you’re a gastroenterologist, it should sound familiar because this pathologic duo also causes colon polyps and Barrett’s Esophagus. Eczema and psoriasis–inflammation/hyperplasia.

Probably the most important concept in medicine is the Law of Parsimony. Find the simplest explanation to explain consequences. In jurisprudence, it’s called “Occam’s Razor”. The simple answer to why these seemingly disparate conditions have such similar features is that they are all actually different manifestations of the same pathophysiology. Richard Kimball, Ruben Carter, and Andy Dufrain will tell you the simple answer is not always correct, however, it’s where you start. Hoof beats in Amarillo are more likely from horses, not zebras.

When you read deeper into these review articles, pathological biochemistry and physiology are outlined. Again, whether it’s Hashimoto’s, acne, pancreatitis, IBS, MS, Alzheimer’s, or asthma, you’ll find “the usual suspects”. The pattern is initialized by an aggregation of monocytes to a specific area. These monocytes then pleomorph into macrophages. Macrophages use cytokinetic mechanisms to attract killer T cells. T-cells, along with macrophages, then produce an elaborate array of chemicals called cytokines that are responsible for the pathology in each condition. The MSU way of dealing with these conditions is to mute or mitigate the immune system response. This then leads to the creation of new diseases like Progressive Multifocal Leukoencephalopathy (PML).

Back to the Law of Parsimony. If the exact same immune system response is being described in each scenario, it makes sense that in each case the immune system is activated by a common pathogen(s). This is what I came up with when I kept seeing a parallel in outcomes with statin drugs and aspirin. If their putative mechanisms of action are so different, why were they causing similar outcomes? There had to be something common between them.

I knew that aspirin, derived from the white willow tree, was a potent anti-fungal. Could it be that statins were also anti-fungals? By this time, it was clear in the medical literature that it didn’t matter if cholesterol went up, down, or sideways. What mattered was the anti-inflammatory effect of statins.

What made the hypothesis more compelling was the fact that the first economically viable statin, Mevacor, was an elaborant from the red yeast rice plant called “lovastatin”. Plants don’t have cholesterol. They also don’t have an immune system. Surviving in an ambient environment of critters means they have to find ways to keep critters at bay. This could be bark, husks, peels, shells or they could make their own pesticides/fungicides. This is the function of lovastatin in red yeast rice. It’s an anti-fungal.

(Much longer than I set out to pen but stick with me. This is revolutionary info that rewrites the textbooks of medicine).

If statins are anti-fungals, they should kill Candida yeast. Moreover, the more potent the statin at lowering cholesterol, the better it should be at killing Candida. To that end, I plated agar filled petri dishes with Candida. I then added a solution of Mevacor, Lipitor, or Crestor to each dish. This is the order of their respective potencies. Results–the Mevacor weakly killed Candida. The Lipitor left a bigger zone of exclusion. Crestor worked better than Lipitor. Soooooo, it does turn out that statins are expensive anti-fungals that reduce inflammation most likely because they reduce Candida levels in the liver (Glycochemistry is used such that statins target liver tissue).

Soooooo, how do I get the Wizard of Awes outcomes with everything from acne to rheumatoid arthritis to vascular disease to psoriasis without having a license to practice medicine? The key is re-establishing autonomic homeostasis–that state of health that automatically keeps critters under control. Most medical conditions are consequences, like being drunk. You don’t need a medical license to tell someone they can improve their condition by not taking in excessive amounts of alcohol.

Note the cherry tomatoes. All bought at the same time. All left in the same bag and not refrigerated. This was not an intentional experiment, just a consequence of being a bachelor. Note the fungal overgrowth in a few, not all. Why? Fungi, like other scavengers, will attack the weak. Some innate (genetic) vulnerability made some tomatoes a more attractive target for the fungus.

Why do certain conditions run in families? Because these genetic weak spots (genetic polymorphisms) get passed from one generation to another. This is manifested in the anatomically symmetrical presentation of conditions like R. A., vitiligo, and eczema. The difference in humans is that once Candida starts to overgrow, the immune system is activated to start the inflammatory sequence that leads to inflammation and hyperplasia.

Easiest way to start reversing these conditions? Incorporate foods that bring critter levels down. Delete foods that raise blood sugar and feed critters. Add foods that are high in critter killers. This is accomplished with the BALi Eating Plan. BALi is the only eating plan with a stated objective of reducing your critter count by relying on natural critter killers found in produce.

Next, the environment must be made critter unfriendly. Had I put those tomatoes in the refrigerator, it would have been harder for the fungus to grow. There is a temperature range that critters do well in. The buffet line keeps food above that temperature range. Refrigeration keeps temperatures below that temperature range.

Thyroid hormone is the body’s sterno can. Thyroid hormone allows us and other mammals to maintain a body temperature that is unfriendly to Candida. As thyroid levels decline, starting around age 27, body temperature starts to decline into the critter growing range. This is when we typically start to see an increase in the incidence of medical conditions associated with inflammation and genetics. Why was your blood sugar, blood pressure and cholesterol normal in your youth but elevated with age? What changed? Simply optimizing thyroid hormone to bring body temperatures back up will automatically reduce critter levels similar to the way heating food gets rid of critters.

There are some nutritional supplements like black seed oil, hydrochloric acid, vitamin D3, etc., that I add in. The Whether Report lets me know what’s needed. However, changing what the patient eats and optimizing thyroid hormone are sine que nons.

Click an image to view larger.

(MSU is a commonly used Robyism that typically stands for “make science up” or “make sh*t up”. “Critter” is commonly used to reference Candida yeast overgrowth and inflammation.)

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Category: General Health, Inflammation, Joint Health

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